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ADNI_130_S_5059_MR_MPRAGE_br_raw_20130212105012862_33_S182011_I358776

On a T1-weighted brain MRI of a 73-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on middle temporal gyrus - mild focal atrophy of occipital lobe on middle occipital gyrus - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - mild left atrophy of the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_109_S_4499_MR_Accelerated_SAG_IR-SPGR__br_raw_20120308134823031_124_S143188_I288998

On a T1-weighted brain MRI of a 84-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of parietal lobe on postcentral gyrus medial segment - mild focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild right atrophy of the basal forebrain - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_123_S_4362_MR_MPRAGE_br_raw_20111129132100892_17_S131210_I269078

On a T1-weighted brain MRI of a 68-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on inf. temporal gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_024_S_4280_MR_MPRAGE_br_raw_20111018163207473_117_S125582_I261332

On a T1-weighted brain MRI of a 80-year-old male subject, we observed the following: For the cerebral cortex: - mild atrophy of the limbic cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: entorhinal area (mild) and parahippocampal gyrus (mild) - moderate focal atrophy of frontal lobe on posterior orbital gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the right - moderate bilateral atrophy of the hippocampus - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - moderate enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

AD

ADNI_037_S_5162_MR_MPRAGE_br_raw_20130503091904515_4_S188623_I369977

On a T1-weighted brain MRI of a 70-year-old male subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the insular cortex, with focal volume reduction observed in the following subregions: central operculum (mild) - atrophies of frontal lobe on orbital inf. frontal gyrus (mild) and posterior orbital gyrus (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - no evidence of atrophy in the ventral dc - no evidence of atrophy in the caudate - no evidence of atrophy in the amygdala - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

AD

ADNI_003_S_4142_MR_Accelerated_SAG_IR-SPGR__br_raw_20110906152028494_176_S121316_I254890

On a T1-weighted brain MRI of a 90-year-old female subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on gyrus rectus (mild) and medial frontal cortex (mild) - atrophies of temporal lobe on planum temporale (mild) and transverse temporal gyrus (mild) - mild focal atrophy of parietal lobe on precuneus - atrophies of limbic cortex on posterior cingulate gyrus (severe) and anterior cingulate gyrus (mild) - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_024_S_5054_MR_MPRAGE_br_raw_20121220180216980_73_S178405_I352573

On a T1-weighted brain MRI of a 74-year-old female subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the occipital lobe, with focal volume reduction observed in the following subregions: occipital fusiform gyrus (mild) and occipital pole (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_016_S_4951_MR_Accelerated_SAG_IR-SPGR__br_raw_20121002084753501_183_S169335_I337687

On a T1-weighted brain MRI of a 72-year-old female subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_082_S_4339_MR_MPRAGE_br_raw_20111110142444516_129_S128898_I265938

On a T1-weighted brain MRI of a 85-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on orbital inf. frontal gyrus (mild) and sup. frontal gyrus (mild) - atrophies of temporal lobe on transverse temporal gyrus (moderate), planum temporale (mild) and sup. temporal gyrus (mild) - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_011_S_4222_MR_MPRAGE_br_raw_20110919103728374_75_S122659_I256865

On a T1-weighted brain MRI of a 83-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on precentral gyrus medial segment - mild focal atrophy of occipital lobe on calcarine cortex - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - moderate bilateral atrophy of the hippocampus, more pronounced on the left - mild atrophy of the putamen, more pronounced on the left - mild atrophy of the pallidum - mild left atrophy of the amygdala - mild left atrophy of the ventral dc - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_031_S_4218_MR_MPRAGE_br_raw_20110915140520234_92_S122024_I255978

On a T1-weighted brain MRI of a 81-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on posterior orbital gyrus - mild focal atrophy of parietal lobe on supramarginal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_941_S_4292_MR_MPRAGE_br_raw_20111205142922369_89_S131754_I269843

On a T1-weighted brain MRI of a 72-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of parietal lobe on angular gyrus - mild focal atrophy of occipital lobe on lingual gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_135_S_5015_MR_MPRAGE_br_raw_20121113152042237_162_S174375_I346353

On a T1-weighted brain MRI of a 78-year-old female subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on gyrus rectus (mild) and supplementary motor cortex (mild) - moderate focal atrophy of temporal lobe on middle temporal gyrus - mild focal atrophy of occipital lobe on calcarine cortex - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - moderate bilateral atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild bilateral enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_007_S_4911_MR_Accelerated_SAG_IR-SPGR__br_raw_20120830145649374_62_S164218_I328209

On a T1-weighted brain MRI of a 75-year-old male subject, we observed the following: For the cerebral cortex: - mild atrophy of the temporal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: middle temporal gyrus (severe), inf. temporal gyrus (mild) and temporal pole (mild) - mild atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: precuneus (moderate) and angular gyrus (mild) - mild focal atrophy of frontal lobe on sup. frontal gyrus medial segment - mild focal atrophy of limbic cortex on posterior cingulate gyrus - mild focal atrophy of insular cortex on parietal operculum - no evidence of atrophy in the occipital lobe For the subcortical structures: - mild atrophy of the amygdala, more pronounced on the right - no evidence of atrophy in the thalamus - mild right atrophy of the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the hippocampus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the pallidum For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - severe bilateral enlargement of the lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_005_S_4910_MR_Accelerated_Sag_IR-SPGR__br_raw_20120924133811005_135_S168559_I336537

On a T1-weighted brain MRI of a 82-year-old female subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the temporal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: inf. temporal gyrus (moderate), sup. temporal gyrus (moderate), planum temporale (moderate), fusiform gyrus (mild), middle temporal gyrus (mild) and temporal pole (mild) - moderate bilateral atrophy of the insular cortex, with focal volume reduction observed in the following subregions: anterior insula (severe) and posterior insula (mild) - mild atrophy of the limbic cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (mild) - atrophies of frontal lobe on medial frontal cortex (moderate), medial orbital gyrus (mild), gyrus rectus (mild) and orbital inf. frontal gyrus (mild) - mild focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the parietal lobe For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the right - mild atrophy of the hippocampus, more pronounced on the right - mild bilateral atrophy of the caudate - mild atrophy of the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe enlargement of the inf. lateral ventricle, more pronounced on the right - mild right enlargement of the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_036_S_4740_MR_MPRAGE_br_raw_20120531115018775_6_S151616_I306469

On a T1-weighted brain MRI of a 89-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on transverse temporal gyrus - mild focal atrophy of parietal lobe on supramarginal gyrus - mild focal atrophy of occipital lobe on calcarine cortex - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - moderate atrophy of the amygdala, more pronounced on the left - moderate bilateral atrophy of the ventral dc - mild atrophy of the caudate, more pronounced on the left - mild atrophy of the basal forebrain - no evidence of atrophy in the accumbens - mild left atrophy of the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - mild left enlargement of the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - mild enlargement of the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

AD

ADNI_035_S_4082_MR_MPRAGE_br_raw_20110628172140545_27_S112905_I242274

On a T1-weighted brain MRI of a 76-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on medial frontal cortex - mild focal atrophy of temporal lobe on inf. temporal gyrus - mild focal atrophy of occipital lobe on sup. occipital gyrus - mild focal atrophy of limbic cortex on entorhinal area - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the putamen - mild left atrophy of the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

CN

ADNI_003_S_4152_MR_Accelerated_SAG_IR-SPGR__br_raw_20110831165853179_106_S120804_I253758

On a T1-weighted brain MRI of a 61-year-old male subject, we observed the following: For the cerebral cortex: - mild atrophy of the parietal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: angular gyrus (mild) - mild atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: middle temporal gyrus (mild), temporal pole (mild) and sup. temporal gyrus (mild) - mild atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: middle cingulate gyrus (mild) - severe focal atrophy of frontal lobe on middle frontal gyrus - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - moderate bilateral atrophy of the caudate, more pronounced on the left - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - mild enlargement of the lateral ventricle, more pronounced on the left - moderate enlargement of the external csf - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle

AD

ADNI_153_S_4172_MR_MPRAGE_br_raw_20110817113413375_135_S119196_I251187

On a T1-weighted brain MRI of a 76-year-old male subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: supramarginal gyrus (mild) - mild bilateral atrophy of the insular cortex, with focal volume reduction observed in the following subregions: parietal operculum (mild) - mild focal atrophy of frontal lobe on middle frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - moderate bilateral atrophy of the caudate, more pronounced on the left - moderate bilateral atrophy of the putamen, more pronounced on the left - mild atrophy of the accumbens, more pronounced on the left - no evidence of atrophy in the amygdala - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

NIFD_1_S_0039_MR_t1_mprage_S9_DIS3D_br_raw_20110422210646858_48_S105044_I228811

On a T1-weighted brain MRI of a 67-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: middle frontal gyrus (severe), gyrus rectus (severe), lateral orbital gyrus (severe), medial orbital gyrus (severe), posterior orbital gyrus (severe), sup. frontal gyrus (severe), sup. frontal gyrus medial segment (severe), frontal pole (moderate), anterior orbital gyrus (severe), opercular inf. frontal gyrus (moderate), supplementary motor cortex (mild), triangular inf. frontal gyrus (moderate), medial frontal cortex (moderate), orbital inf. frontal gyrus (mild) and precentral gyrus (mild) - severe bilateral atrophy of the insular cortex, with focal volume reduction observed in the following subregions: anterior insula (severe), posterior insula (moderate) and frontal operculum (mild) - severe bilateral atrophy of the limbic cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (severe), entorhinal area (mild) and middle cingulate gyrus (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the accumbens, more pronounced on the right - severe bilateral atrophy of the amygdala, more pronounced on the right - severe bilateral atrophy of the caudate, more pronounced on the right - severe bilateral atrophy of the putamen, more pronounced on the right - moderate bilateral atrophy of the hippocampus, more pronounced on the right - mild atrophy of the pallidum, more pronounced on the right - mild atrophy of the thalamus, more pronounced on the right - no evidence of atrophy in the ventral dc - no evidence of atrophy in the basal forebrain For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - severe bilateral enlargement of the lateral ventricle - severe enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0015_MR_t1_mprage_S3_DIS3D_br_raw_20110204144009602_54_S99058_I215997

On a T1-weighted brain MRI of a 63-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: temporal pole (severe), fusiform gyrus (severe), inf. temporal gyrus (moderate), planum polare (mild), middle temporal gyrus (mild) and sup. temporal gyrus (mild) - moderate atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (severe) and posterior insula (moderate) - mild bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: entorhinal area (severe) - mild focal atrophy of frontal lobe on sup. frontal gyrus medial segment - mild focal atrophy of parietal lobe on postcentral gyrus medial segment - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - moderate atrophy of the hippocampus, more pronounced on the left - moderate bilateral atrophy of the accumbens, more pronounced on the left - no evidence of atrophy in the basal forebrain - moderate left atrophy of the putamen - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the caudate - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - moderate enlargement of the 3rd ventricle - moderate enlargement of the external csf - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0016_MR_t1_mprage_S3_DIS3D_br_raw_20110203204329152_98_S98904_I215791

On a T1-weighted brain MRI of a 69-year-old female subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: precentral gyrus (severe), middle frontal gyrus (moderate), opercular inf. frontal gyrus (mild) and posterior orbital gyrus (mild) - moderate bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: angular gyrus (mild) - moderate focal atrophy of temporal lobe on middle temporal gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the caudate, more pronounced on the right - severe bilateral atrophy of the putamen, more pronounced on the right - severe bilateral atrophy of the pallidum, more pronounced on the right - severe bilateral atrophy of the thalamus, more pronounced on the right - moderate bilateral atrophy of the accumbens - moderate bilateral atrophy of the ventral dc, more pronounced on the right - mild bilateral atrophy of the amygdala - mild atrophy of the basal forebrain - no evidence of atrophy in the hippocampus For the ventricles: - moderate bilateral enlargement of the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - severe enlargement of the external csf - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_2_S_0014_MR_MT1__GradWarp__N3m_Br_20111229191004875_S134530_I274739

On a T1-weighted brain MRI of a 53-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the parietal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: sup. parietal lobule (mild) and supramarginal gyrus (mild) - severe bilateral atrophy of the insular cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: central operculum (moderate) and anterior insula (mild) - moderate bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: posterior orbital gyrus (moderate), middle frontal gyrus (mild), gyrus rectus (mild) and sup. frontal gyrus (mild) - atrophies of temporal lobe on sup. temporal gyrus (mild) and temporal pole (mild) - atrophies of occipital lobe on cuneus (mild) and middle occipital gyrus (mild) - mild focal atrophy of limbic cortex on anterior cingulate gyrus For the subcortical structures: - severe bilateral atrophy of the accumbens, more pronounced on the left - severe bilateral atrophy of the caudate - moderate bilateral atrophy of the pallidum - moderate bilateral atrophy of the putamen - mild bilateral atrophy of the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the lateral ventricle - severe bilateral enlargement of the inf. lateral ventricle - severe enlargement of the external csf - mild enlargement of the 3rd ventricle - mild enlargement of the 4th ventricle

FTD

NIFD_1_S_0124_MR_T1_mprage_S3_DIS3D_br_raw_20170816174454166_9_S596959_I890107

On a T1-weighted brain MRI of a 73-year-old female subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (severe), frontal operculum (moderate) and central operculum (mild) - mild atrophy of the frontal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: triangular inf. frontal gyrus (moderate), supplementary motor cortex (moderate), opercular inf. frontal gyrus (mild), precentral gyrus (mild) and posterior orbital gyrus (mild) - mild focal atrophy of occipital lobe on occipital pole - mild focal atrophy of limbic cortex on middle cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe For the subcortical structures: - severe bilateral atrophy of the caudate, more pronounced on the left - severe bilateral atrophy of the pallidum, more pronounced on the left - severe bilateral atrophy of the putamen, more pronounced on the left - severe bilateral atrophy of the accumbens - moderate atrophy of the amygdala, more pronounced on the left - mild bilateral atrophy of the ventral dc - mild left atrophy of the thalamus - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle, more pronounced on the left - severe bilateral enlargement of the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0121_MR_T1_mprage_S3_DIS3D_br_raw_20130123075818773_100_S180679_I355811

On a T1-weighted brain MRI of a 59-year-old female subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the thalamus - mild left atrophy of the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - mild enlargement of the inf. lateral ventricle, more pronounced on the right - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0234_MR_t1_mprage__br_raw_20170814174829946_20_S594393_I886861

On a T1-weighted brain MRI of a 63-year-old female subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe - mild focal atrophy of frontal lobe on posterior orbital gyrus - mild focal atrophy of insular cortex on parietal operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0269_MR_t1_mprage__br_raw_20160902220526927_82_S496410_I772673

On a T1-weighted brain MRI of a 63-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on fusiform gyrus - mild focal atrophy of occipital lobe on occipital fusiform gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - mild focal atrophy of insular cortex on posterior insula - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe For the subcortical structures: - mild atrophy of the accumbens, more pronounced on the right - no evidence of atrophy in the ventral dc - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0284_MR_t1_mprage__br_raw_20170628135548125_85_S576477_I865837

On a T1-weighted brain MRI of a 63-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on subcallosal area (moderate), posterior orbital gyrus (mild) and opercular inf. frontal gyrus (mild) - mild focal atrophy of temporal lobe on temporal pole - moderate focal atrophy of insular cortex on central operculum - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - mild atrophy of the hippocampus, more pronounced on the left - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0248_MR_t1_mprage__br_raw_20160902163301918_127_S495952_I772146

On a T1-weighted brain MRI of a 69-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on gyrus rectus (mild) and medial frontal cortex (mild) - mild focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0313_MR_T1_mprage_S3_DIS3D_br_raw_20160909144402197_156_S498093_I774674

On a T1-weighted brain MRI of a 70-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on subcallosal area - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the amygdala - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0180_MR_T1_mprage_S3_DIS3D_br_raw_20140831181136534_50_S229067_I441385

On a T1-weighted brain MRI of a 53-year-old male subject, we observed the following: For the cerebral cortex: - mild atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (mild) - mild focal atrophy of frontal lobe on opercular inf. frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the hippocampus - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0032_MR_t1_mprage_S41_DIS3D__br_raw_20110514204129592_155_S108946_I235070

On a T1-weighted brain MRI of a 60-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: middle frontal gyrus (moderate), precentral gyrus (mild) and posterior orbital gyrus (mild) - mild atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (moderate) and middle cingulate gyrus (mild) - mild atrophy of the insular cortex, with focal volume reduction observed in the following subregions: anterior insula (moderate) - moderate focal atrophy of temporal lobe on temporal pole - mild focal atrophy of occipital lobe on cuneus - no evidence of atrophy in the parietal lobe For the subcortical structures: - moderate bilateral atrophy of the accumbens, more pronounced on the left - moderate bilateral atrophy of the pallidum - mild atrophy of the thalamus, more pronounced on the left - mild atrophy of the amygdala, more pronounced on the left - no evidence of atrophy in the basal forebrain - mild bilateral atrophy of the ventral dc - mild left atrophy of the hippocampus - mild left atrophy of the putamen - mild left atrophy of the caudate For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - severe enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0053_MR_T1_mprage_S3_DIS3D_br_raw_20170817095339381_67_S597254_I890544

On a T1-weighted brain MRI of a 69-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the temporal lobe, with focal volume reduction observed in the following subregions: fusiform gyrus (severe), temporal pole (severe), inf. temporal gyrus (severe) and planum temporale (mild) - severe bilateral atrophy of the insular cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: anterior insula (severe), posterior insula (moderate) and parietal operculum (mild) - moderate bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (severe) and entorhinal area (mild) - mild focal atrophy of frontal lobe on subcallosal area - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the accumbens, more pronounced on the right - severe bilateral atrophy of the amygdala - severe bilateral atrophy of the hippocampus - mild atrophy of the putamen, more pronounced on the left - no evidence of atrophy in the thalamus - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - mild left enlargement of the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0061_MR_t1_mprage_S3_DIS3D_br_raw_20111215102518636_37_S133273_I272123

On a T1-weighted brain MRI of a 53-year-old female subject, we observed the following: For the cerebral cortex: - moderate atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (moderate), posterior insula (mild) and frontal operculum (mild) - mild atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: inf. temporal gyrus (moderate), fusiform gyrus (mild), planum temporale (mild) and temporal pole (mild) - mild atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: parahippocampal gyrus (mild) and anterior cingulate gyrus (mild) - mild focal atrophy of frontal lobe on opercular inf. frontal gyrus - mild focal atrophy of parietal lobe on supramarginal gyrus - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - no evidence of atrophy in the basal forebrain - mild left atrophy of the hippocampus - mild left atrophy of the putamen - mild left atrophy of the caudate - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - moderate enlargement of the inf. lateral ventricle, more pronounced on the left - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0091_MR_T1_mprage_S3_DIS3D_br_raw_20170817104021048_43_S597455_I890811

On a T1-weighted brain MRI of a 57-year-old male subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the insular cortex, with focal volume reduction observed in the following subregions: posterior insula (moderate) and parietal operculum (mild) - atrophies of frontal lobe on anterior orbital gyrus (mild) and posterior orbital gyrus (mild) - mild focal atrophy of limbic cortex on posterior cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - moderate bilateral atrophy of the thalamus - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0095_MR_T1_mprage_S3_DIS3D_br_raw_20120819163606804_114_S161475_I324728

On a T1-weighted brain MRI of a 73-year-old female subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: middle frontal gyrus (moderate), medial frontal cortex (moderate), gyrus rectus (mild), medial orbital gyrus (mild), frontal pole (mild), orbital inf. frontal gyrus (mild) and sup. frontal gyrus medial segment (mild) - moderate bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (moderate) and parahippocampal gyrus (mild) - mild focal atrophy of occipital lobe on occipital pole - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - severe bilateral atrophy of the accumbens, more pronounced on the left - severe bilateral atrophy of the caudate - no evidence of atrophy in the basal forebrain - moderate bilateral atrophy of the putamen - moderate bilateral atrophy of the thalamus - mild bilateral atrophy of the pallidum - mild atrophy of the hippocampus - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - severe bilateral enlargement of the lateral ventricle - severe enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0099_MR_T1_mprage_S3_DIS3D_br_raw_20120819131043923_110_S161401_I324640

On a T1-weighted brain MRI of a 69-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on triangular inf. frontal gyrus - mild focal atrophy of temporal lobe on sup. temporal gyrus - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - moderate bilateral atrophy of the putamen, more pronounced on the left - moderate bilateral atrophy of the caudate - mild bilateral atrophy of the accumbens - mild atrophy of the pallidum - mild left atrophy of the thalamus - no evidence of atrophy in the hippocampus - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0112_MR_T1_mprage_S5_DIS3D_br_raw_20170816153347354_122_S596472_I889436

On a T1-weighted brain MRI of a 78-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of limbic cortex on middle cingulate gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - severe bilateral atrophy of the putamen, more pronounced on the right - moderate bilateral atrophy of the accumbens - moderate right atrophy of the pallidum - no evidence of atrophy in the ventral dc - mild right atrophy of the caudate - no evidence of atrophy in the thalamus - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0172_MR_T1_mprage_S3_DIS3D_br_raw_20170815192237721_95_S223956_I434045

On a T1-weighted brain MRI of a 60-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: inf. temporal gyrus (severe), temporal pole (severe), fusiform gyrus (moderate), planum temporale (moderate), planum polare (mild), middle temporal gyrus (mild), sup. temporal gyrus (mild) and transverse temporal gyrus (mild) - severe bilateral atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: posterior insula (severe), anterior insula (severe), central operculum (mild) and parietal operculum (mild) - atrophies of limbic cortex on entorhinal area (severe) and parahippocampal gyrus (moderate) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - moderate bilateral atrophy of the hippocampus, more pronounced on the left - no evidence of atrophy in the basal forebrain - mild atrophy of the accumbens, more pronounced on the left - mild atrophy of the putamen, more pronounced on the left - mild atrophy of the caudate, more pronounced on the left - mild left atrophy of the thalamus - mild left atrophy of the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle, more pronounced on the left - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0322_MR_t1_mprage__br_raw_20170628162001259_142_S576863_I866324

On a T1-weighted brain MRI of a 45-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: middle frontal gyrus (moderate), sup. frontal gyrus medial segment (moderate), frontal pole (mild), medial frontal cortex (mild) and sup. frontal gyrus (mild) - mild focal atrophy of limbic cortex on anterior cingulate gyrus - atrophies of insular cortex on central operculum (mild) and frontal operculum (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - moderate bilateral atrophy of the caudate, more pronounced on the left - mild bilateral atrophy of the putamen, more pronounced on the left - mild bilateral atrophy of the thalamus - mild atrophy of the pallidum - mild left atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the ventral dc For the ventricles: - moderate bilateral enlargement of the lateral ventricle - moderate enlargement of the inf. lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0324_MR_t1_mprage__br_raw_20170628163333846_44_S576938_I866414

On a T1-weighted brain MRI of a 58-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the insular cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: anterior insula (severe), posterior insula (severe), central operculum (severe), parietal operculum (moderate) and frontal operculum (mild) - severe bilateral atrophy of the frontal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: medial orbital gyrus (moderate), sup. frontal gyrus (moderate), middle frontal gyrus (mild), posterior orbital gyrus (moderate), gyrus rectus (mild), precentral gyrus (mild), triangular inf. frontal gyrus (mild), sup. frontal gyrus medial segment (mild) and anterior orbital gyrus (mild) - severe bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (severe), middle cingulate gyrus (moderate) and entorhinal area (mild) - mild atrophy of the parietal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: supramarginal gyrus (mild) and postcentral gyrus (mild) - atrophies of temporal lobe on middle temporal gyrus (moderate) and inf. temporal gyrus (mild) - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the accumbens, more pronounced on the right - severe bilateral atrophy of the putamen, more pronounced on the right - severe bilateral atrophy of the amygdala, more pronounced on the right - severe bilateral atrophy of the caudate, more pronounced on the right - no evidence of atrophy in the ventral dc - no evidence of atrophy in the basal forebrain - mild right atrophy of the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle, more pronounced on the right - moderate bilateral enlargement of the lateral ventricle - severe enlargement of the external csf - moderate enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0023_MR_t1_mprage_S3_DIS3D_br_raw_20110204130939593_99_S99047_I215985

On a T1-weighted brain MRI of a 67-year-old male subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the hippocampus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

CN

NIFD_1_S_0131_MR_T1_mprage_S3_DIS3D_br_raw_20130723102305083_133_S196174_I382122

On a T1-weighted brain MRI of a 70-year-old female subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on posterior orbital gyrus (moderate) and medial frontal cortex (mild) - mild focal atrophy of parietal lobe on postcentral gyrus medial segment - mild focal atrophy of insular cortex on parietal operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the ventral dc - no evidence of atrophy in the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0228_MR_T1_mprage_S3_DIS3D_br_raw_20150129181523748_47_S246788_I470886

On a T1-weighted brain MRI of a 55-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild right atrophy of the accumbens - no evidence of atrophy in the pallidum - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0238_MR_t1_mprage__br_raw_20160902144226204_127_S495765_I771932

On a T1-weighted brain MRI of a 67-year-old male subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild right atrophy of the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0264_MR_t1_mprage__br_raw_20160902204620868_5_S496270_I772517

On a T1-weighted brain MRI of a 60-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on inf. temporal gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0265_MR_T1_mprage_S3_DIS3D_br_raw_20170815145928316_20_S595662_I888373

On a T1-weighted brain MRI of a 67-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on medial frontal cortex (moderate) and lateral orbital gyrus (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild right atrophy of the amygdala - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0274_MR_t1_mprage__br_raw_20170814134905743_51_S576431_I865780

On a T1-weighted brain MRI of a 70-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_014_S_4576_MR_MPRAGE_br_raw_20120309091136349_1_S143423_I289484

On a T1-weighted brain MRI of a 71-year-old female subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the occipital lobe, with focal volume reduction observed in the following subregions: cuneus (moderate), calcarine cortex (mild) and inf. occipital gyrus (mild) - atrophies of parietal lobe on postcentral gyrus medial segment (mild) and precuneus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - mild left atrophy of the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_068_S_4859_MR_MPRAGE_br_raw_20120807164257395_107_S159890_I322076

On a T1-weighted brain MRI of a 73-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on precentral gyrus (mild) and middle frontal gyrus (mild) - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - mild atrophy of the hippocampus, more pronounced on the right - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the lateral ventricle - severe bilateral enlargement of the inf. lateral ventricle - moderate enlargement of the 3rd ventricle - no evidence of enlargements in the external csf - no evidence of enlargements in the 4th ventricle

AD

ADNI_130_S_4660_MR_MPRAGE_br_raw_20120423092147818_143_S148079_I300034

On a T1-weighted brain MRI of a 78-year-old female subject, we observed the following: For the cerebral cortex: - mild atrophy of the parietal lobe, more pronounced on the left - moderate focal atrophy of frontal lobe on gyrus rectus - mild focal atrophy of temporal lobe on inf. temporal gyrus - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the hippocampus - mild left atrophy of the pallidum - mild right atrophy of the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

AD

ADNI_002_S_4262_MR_MPRAGE_br_raw_20111005162027440_65_S124482_I259653

On a T1-weighted brain MRI of a 73-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on fusiform gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - moderate bilateral atrophy of the accumbens, more pronounced on the right - mild bilateral atrophy of the pallidum - mild bilateral atrophy of the putamen - no evidence of atrophy in the hippocampus - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild enlargement of the inf. lateral ventricle - mild enlargement of the lateral ventricle, more pronounced on the right - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_002_S_4225_MR_MPRAGE_br_raw_20110921132806051_4_S122881_I257270

On a T1-weighted brain MRI of a 70-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on precentral gyrus medial segment (mild), triangular inf. frontal gyrus (mild) and gyrus rectus (mild) - mild focal atrophy of occipital lobe on middle occipital gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

CN

ADNI_003_S_4350_MR_Accelerated_SAG_IR-SPGR__br_raw_20111209155941600_161_S132520_I271010

On a T1-weighted brain MRI of a 73-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of insular cortex on parietal operculum - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_005_S_4707_MR_Accelerated_Sag_IR-SPGR__br_raw_20120516113228861_186_S150618_I304670

On a T1-weighted brain MRI of a 68-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on middle temporal gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

AD

ADNI_023_S_4164_MR_MPRAGE_br_raw_20110908132522790_74_S120705_I253488

On a T1-weighted brain MRI of a 73-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on frontal pole (moderate), gyrus rectus (moderate), medial orbital gyrus (mild) and sup. frontal gyrus medial segment (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_067_S_5205_MR_MPRAGE_br_raw_20130617123032185_46_S192528_I376818

On a T1-weighted brain MRI of a 60-year-old female subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: middle frontal gyrus (severe), anterior orbital gyrus (mild), sup. frontal gyrus (mild) and medial frontal cortex (mild) - moderate bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: supramarginal gyrus (moderate), angular gyrus (mild) and precuneus (mild) - mild focal atrophy of insular cortex on frontal operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - no evidence of atrophy in the pallidum - mild bilateral atrophy of the amygdala - no evidence of atrophy in the ventral dc - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the hippocampus - no evidence of atrophy in the thalamus For the ventricles: - mild enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - moderate enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

AD

ADNI_005_S_5119_MR_Accelerated_Sag_IR-FSPGR___br_raw_20130328164636279_189_S185468_I364846

On a T1-weighted brain MRI of a 77-year-old female subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on frontal pole (mild) and medial frontal cortex (mild) - mild focal atrophy of temporal lobe on middle temporal gyrus - mild focal atrophy of parietal lobe on angular gyrus - mild focal atrophy of occipital lobe on inf. occipital gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the amygdala - mild right atrophy of the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 4th ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle

AD

ADNI_007_S_4387_MR_Accelerated_SAG_IR-SPGR__br_raw_20111205145639270_31_S131808_I269927

On a T1-weighted brain MRI of a 76-year-old female subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_137_S_4632_MR_MPRAGE_br_raw_20120504083149505_11_S149075_I301663

On a T1-weighted brain MRI of a 68-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on lateral orbital gyrus (moderate), frontal pole (mild) and precentral gyrus (mild) - mild focal atrophy of parietal lobe on postcentral gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_016_S_4121_MR_Accelerated_SAG_IR-SPGR__br_raw_20110721110431807_155_S115573_I246007

On a T1-weighted brain MRI of a 89-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on subcallosal area - mild focal atrophy of limbic cortex on posterior cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - moderate atrophy of the thalamus, more pronounced on the right - mild atrophy of the ventral dc, more pronounced on the right - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_016_S_4638_MR_Accelerated_SAG_IR-SPGR__br_raw_20120522105327181_179_S151234_I305876

On a T1-weighted brain MRI of a 74-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on gyrus rectus (mild) and medial frontal cortex (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_070_S_4719_MR_MPRAGE_br_raw_20120521142246850_171_S151143_I305573

On a T1-weighted brain MRI of a 80-year-old female subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the temporal lobe, with focal volume reduction observed in the following subregions: fusiform gyrus (mild), temporal pole (mild), sup. temporal gyrus (mild) and planum temporale (mild) - mild atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: precuneus (mild), sup. parietal lobule (mild) and postcentral gyrus (mild) - mild atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: parahippocampal gyrus (moderate) and posterior cingulate gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - moderate atrophy of the amygdala, more pronounced on the left - mild atrophy of the hippocampus, more pronounced on the left - no evidence of atrophy in the thalamus - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen For the ventricles: - mild left enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_014_S_4577_MR_MPRAGE_br_raw_20120322131214248_143_S144503_I291667

On a T1-weighted brain MRI of a 85-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on supplementary motor cortex - atrophies of occipital lobe on occipital fusiform gyrus (mild) and inf. occipital gyrus (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the thalamus - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_003_S_4136_MR_Accelerated_SAG_IR-SPGR__br_raw_20110811161151865_120_S118498_I250168

On a T1-weighted brain MRI of a 67-year-old male subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: precuneus (mild) - mild atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: posterior orbital gyrus (mild) - moderate focal atrophy of temporal lobe on inf. temporal gyrus - mild focal atrophy of limbic cortex on posterior cingulate gyrus - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the occipital lobe For the subcortical structures: - moderate bilateral atrophy of the amygdala, more pronounced on the right - mild atrophy of the hippocampus, more pronounced on the right - mild left atrophy of the putamen - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the thalamus For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - severe bilateral enlargement of the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_003_S_4555_MR_Accelerated_SAG_IR-SPGR__br_raw_20120321093758064_53_S144333_I291317

On a T1-weighted brain MRI of a 66-year-old female subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_127_S_4198_MR_Accelerated_Sag_IR-SPGR__br_raw_20110902083648052_131_S121087_I254317

On a T1-weighted brain MRI of a 78-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on medial frontal cortex - mild focal atrophy of parietal lobe on postcentral gyrus - mild focal atrophy of occipital lobe on calcarine cortex - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_082_S_4224_MR_MPRAGE_br_raw_20110921173809009_175_S122960_I257382

On a T1-weighted brain MRI of a 76-year-old male subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_013_S_4731_MR_MPRAGE_br_raw_20120605171549316_130_S152822_I308178

On a T1-weighted brain MRI of a 83-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on planum temporale - mild focal atrophy of occipital lobe on occipital pole - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the amygdala, more pronounced on the left - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc - mild atrophy of the hippocampus - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the accumbens - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_019_S_4549_MR_MPRAGE_br_raw_20120424183948590_139_S148210_I300335

On a T1-weighted brain MRI of a 80-year-old male subject, we observed the following: For the cerebral cortex: - mild atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: angular gyrus (mild) and supramarginal gyrus (mild) - mild atrophy of the insular cortex, with focal volume reduction observed in the following subregions: anterior insula (mild) - mild focal atrophy of frontal lobe on triangular inf. frontal gyrus - atrophies of temporal lobe on middle temporal gyrus (mild) and inf. temporal gyrus (mild) - mild focal atrophy of occipital lobe on inf. occipital gyrus - mild focal atrophy of limbic cortex on parahippocampal gyrus For the subcortical structures: - mild atrophy of the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_072_S_4103_MR_MPRAGE_br_raw_20110721105250665_38_S115543_I245969

On a T1-weighted brain MRI of a 72-year-old male subject, we observed the following: For the cerebral cortex: - mild atrophy of the parietal lobe, more pronounced on the left - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the accumbens, more pronounced on the right - no evidence of atrophy in the pallidum - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_116_S_4209_MR_MPRAGE_br_raw_20110829150325078_55_S120577_I253231

On a T1-weighted brain MRI of a 78-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on middle temporal gyrus - atrophies of occipital lobe on sup. occipital gyrus (mild) and inf. occipital gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_009_S_5027_MR_MPRAGE_br_raw_20121214085746080_45_S177647_I351495

On a T1-weighted brain MRI of a 76-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on inf. temporal gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the amygdala, more pronounced on the left - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - mild left enlargement of the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_153_S_4372_MR_MPRAGE_br_raw_20111130171431062_134_S131410_I269347

On a T1-weighted brain MRI of a 71-year-old female subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: frontal pole (severe), middle frontal gyrus (moderate), sup. frontal gyrus (mild) and supplementary motor cortex (mild) - mild focal atrophy of temporal lobe on planum polare - mild focal atrophy of occipital lobe on cuneus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the parietal lobe For the subcortical structures: - mild bilateral atrophy of the caudate - mild left atrophy of the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

CN

ADNI_006_S_4192_MR_MPRAGE_br_raw_20110928083832513_147_S123807_I258594

On a T1-weighted brain MRI of a 83-year-old male subject, we observed the following: For the cerebral cortex: - moderate focal atrophy of frontal lobe on sup. frontal gyrus - atrophies of limbic cortex on entorhinal area (mild) and parahippocampal gyrus (mild) - mild focal atrophy of insular cortex on frontal operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - moderate bilateral atrophy of the amygdala - no evidence of atrophy in the thalamus - no evidence of atrophy in the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - moderate bilateral enlargement of the lateral ventricle - mild enlargement of the inf. lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_036_S_4894_MR_MPRAGE_br_raw_20120810124944746_175_S160488_I323094

On a T1-weighted brain MRI of a 61-year-old female subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: supramarginal gyrus (mild) - atrophies of frontal lobe on sup. frontal gyrus (moderate) and opercular inf. frontal gyrus (mild) - atrophies of temporal lobe on inf. temporal gyrus (mild) and middle temporal gyrus (mild) - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - moderate bilateral atrophy of the hippocampus - mild atrophy of the amygdala, more pronounced on the left - mild bilateral atrophy of the caudate - no evidence of atrophy in the basal forebrain - mild left atrophy of the putamen - no evidence of atrophy in the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild enlargement of the inf. lateral ventricle, more pronounced on the left - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

AD

ADNI_051_S_4980_MR_MPRAGE_br_raw_20121030084030420_50_S172619_I343041

On a T1-weighted brain MRI of a 88-year-old male subject, we observed the following: For the cerebral cortex: - mild atrophy of the parietal lobe - mild focal atrophy of frontal lobe on subcallosal area - mild focal atrophy of temporal lobe on planum temporale - mild focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild left atrophy of the caudate - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

AD

ADNI_053_S_5208_MR_MPRAGE_br_raw_20130618080348968_151_S192574_I376939

On a T1-weighted brain MRI of a 69-year-old male subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: sup. parietal lobule (mild) - mild atrophy of the occipital lobe, with focal volume reduction observed in the following subregions: middle occipital gyrus (mild) and sup. occipital gyrus (mild) - mild atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: entorhinal area (mild) - mild focal atrophy of frontal lobe on gyrus rectus - atrophies of temporal lobe on middle temporal gyrus (mild) and temporal pole (mild) - mild focal atrophy of insular cortex on central operculum For the subcortical structures: - severe bilateral atrophy of the hippocampus - moderate bilateral atrophy of the amygdala, more pronounced on the right - mild atrophy of the pallidum, more pronounced on the right - mild atrophy of the thalamus, more pronounced on the right - mild atrophy of the accumbens - mild atrophy of the putamen - mild right atrophy of the ventral dc - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate For the ventricles: - mild enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the 3rd ventricle - mild enlargement of the external csf - no evidence of enlargements in the 4th ventricle

AD

ADNI_031_S_4474_MR_MPRAGE_br_raw_20120124151610231_14_S138337_I280369

On a T1-weighted brain MRI of a 86-year-old male subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_098_S_4018_MR_Accelerated_Sag_IR-SPGR__br_raw_20110422173143430_59_S105026_I228789

On a T1-weighted brain MRI of a 76-year-old male subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: angular gyrus (mild) - mild focal atrophy of temporal lobe on fusiform gyrus - mild focal atrophy of occipital lobe on cuneus - mild focal atrophy of limbic cortex on middle cingulate gyrus - atrophies of insular cortex on anterior insula (mild) and posterior insula (mild) - no evidence of atrophy in the frontal lobe For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - moderate enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

CN

ADNI_068_S_5206_MR_MPRAGE_br_raw_20130708131953934_142_S194175_I379376

On a T1-weighted brain MRI of a 86-year-old male subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: subcallosal area (mild), sup. frontal gyrus (mild) and supplementary motor cortex (mild) - mild atrophy of the insular cortex, with focal volume reduction observed in the following subregions: anterior insula (mild) - moderate focal atrophy of temporal lobe on inf. temporal gyrus - moderate focal atrophy of parietal lobe on postcentral gyrus medial segment - mild focal atrophy of occipital lobe on calcarine cortex - mild focal atrophy of limbic cortex on posterior cingulate gyrus For the subcortical structures: - mild bilateral atrophy of the amygdala - mild atrophy of the hippocampus, more pronounced on the left - no evidence of atrophy in the basal forebrain - mild left atrophy of the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

AD

NIFD_1_S_0132_MR_T1_mprage_S3_DIS3D_br_raw_20130722152424568_4_S196033_I381938

On a T1-weighted brain MRI of a 65-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: gyrus rectus (severe), medial orbital gyrus (severe), sup. frontal gyrus medial segment (severe), frontal pole (moderate), medial frontal cortex (moderate), subcallosal area (moderate), middle frontal gyrus (mild), lateral orbital gyrus (mild), posterior orbital gyrus (mild) and anterior orbital gyrus (mild) - severe bilateral atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (severe), parietal operculum (moderate) and posterior insula (mild) - severe atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: middle temporal gyrus (severe), planum temporale (moderate), inf. temporal gyrus (moderate) and temporal pole (mild) - moderate bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: middle cingulate gyrus (severe) and anterior cingulate gyrus (moderate) - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the caudate, more pronounced on the left - severe bilateral atrophy of the putamen, more pronounced on the left - severe bilateral atrophy of the accumbens - severe bilateral atrophy of the amygdala, more pronounced on the left - moderate bilateral atrophy of the pallidum, more pronounced on the left - no evidence of atrophy in the basal forebrain - mild left atrophy of the thalamus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the hippocampus For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle, more pronounced on the left - moderate enlargement of the lateral ventricle - severe enlargement of the 3rd ventricle - moderate enlargement of the external csf - mild enlargement of the 4th ventricle

FTD

NIFD_1_S_0064_MR_t1_mprage_S3_DIS3D_br_raw_20111019180821812_6_S125843_I261660

On a T1-weighted brain MRI of a 66-year-old female subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on sup. frontal gyrus (moderate) and sup. frontal gyrus medial segment (mild) - mild focal atrophy of temporal lobe on temporal pole - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the putamen - mild atrophy of the accumbens, more pronounced on the right - mild right atrophy of the caudate - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild bilateral enlargement of the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0187_MR_T1_mprage_S3_DIS3D_br_raw_20140901073756573_14_S229276_I441619

On a T1-weighted brain MRI of a 58-year-old female subject, we observed the following: For the cerebral cortex: - mild atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: temporal pole (severe), middle temporal gyrus (moderate) and inf. temporal gyrus (mild) - mild atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: supramarginal gyrus (mild) - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - mild atrophy of the hippocampus, more pronounced on the left - mild atrophy of the accumbens, more pronounced on the left - mild atrophy of the putamen, more pronounced on the left - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the thalamus - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - severe enlargement of the inf. lateral ventricle, more pronounced on the left - no evidence of enlargements in the lateral ventricle - moderate enlargement of the 3rd ventricle - mild enlargement of the external csf - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0041_MR_t1_mprage_S3_DIS3D_br_raw_20110430173200152_32_S106593_I231157

On a T1-weighted brain MRI of a 77-year-old male subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: supramarginal gyrus (mild) - mild atrophy of the insular cortex, more pronounced on the left - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - moderate bilateral atrophy of the putamen, more pronounced on the left - mild bilateral atrophy of the accumbens - mild atrophy of the pallidum - mild atrophy of the thalamus - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0204_MR_T1_mprage_S3_DIS3D_br_raw_20140901105232469_41_S229550_I441930

On a T1-weighted brain MRI of a 74-year-old female subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: middle frontal gyrus (mild), lateral orbital gyrus (mild), precentral gyrus (mild) and medial frontal cortex (mild) - moderate atrophy of the limbic cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (moderate) - mild atrophy of the parietal lobe - mild focal atrophy of temporal lobe on planum polare - mild focal atrophy of insular cortex on frontal operculum - no evidence of atrophy in the occipital lobe For the subcortical structures: - moderate bilateral atrophy of the amygdala - moderate bilateral atrophy of the caudate - mild bilateral atrophy of the accumbens - mild bilateral atrophy of the putamen - mild atrophy of the hippocampus - mild left atrophy of the thalamus - mild right atrophy of the pallidum - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the ventral dc For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - moderate enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0245_MR_t1_mprage__br_raw_20160902154856522_149_S495886_I772073

On a T1-weighted brain MRI of a 66-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on middle frontal gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the accumbens - mild bilateral atrophy of the caudate - mild bilateral atrophy of the thalamus - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the amygdala - mild right atrophy of the pallidum - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For the ventricles: - mild enlargement of the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0171_MR_T1_mprage_S3_DIS3D_br_raw_20170815184406103_49_S260943_I494120

On a T1-weighted brain MRI of a 59-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of limbic cortex on middle cingulate gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_2_S_0003_MR_MT1__GradWarp__N3m_Br_20120509155330787_S133198_I302621

On a T1-weighted brain MRI of a 62-year-old female subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: angular gyrus (mild) - moderate focal atrophy of frontal lobe on middle frontal gyrus - mild focal atrophy of temporal lobe on fusiform gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - moderate enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

CN

NIFD_1_S_0232_MR_t1_mprage__br_raw_20170814132459630_50_S495585_I771721

On a T1-weighted brain MRI of a 63-year-old female subject, we observed the following: For the cerebral cortex: - mild atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: precuneus (mild) - atrophies of limbic cortex on entorhinal area (mild) and parahippocampal gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the amygdala, more pronounced on the right - no evidence of atrophy in the pallidum - mild right atrophy of the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0287_MR_t1_mprage__br_raw_20160903211742055_18_S496783_I773101

On a T1-weighted brain MRI of a 64-year-old male subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0240_MR_t1_mprage__br_raw_20170628114458760_40_S576118_I865402

On a T1-weighted brain MRI of a 75-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on orbital inf. frontal gyrus - mild focal atrophy of temporal lobe on sup. temporal gyrus - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0011_MR_t1_mprage_S3_DIS3D_br_raw_20110203102701100_95_S98797_I215662

On a T1-weighted brain MRI of a 60-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the insular cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: anterior insula (severe), posterior insula (mild), central operculum (mild) and frontal operculum (mild) - severe bilateral atrophy of the frontal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: gyrus rectus (moderate), posterior orbital gyrus (mild), medial frontal cortex (mild), medial orbital gyrus (mild) and sup. frontal gyrus medial segment (mild) - mild atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: postcentral gyrus (mild) - mild atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (moderate) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - moderate bilateral atrophy of the caudate, more pronounced on the right - moderate atrophy of the amygdala, more pronounced on the right - moderate bilateral atrophy of the putamen, more pronounced on the right - moderate bilateral atrophy of the accumbens, more pronounced on the right - no evidence of atrophy in the basal forebrain - mild right atrophy of the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild right enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - moderate enlargement of the 3rd ventricle - moderate enlargement of the external csf - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0035_MR_t1_mprage_S3_DIS3D_br_raw_20110426104720819_116_S105196_I229033

On a T1-weighted brain MRI of a 64-year-old female subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: parahippocampal gyrus (moderate), anterior cingulate gyrus (moderate) and entorhinal area (mild) - severe atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: inf. temporal gyrus (severe), fusiform gyrus (moderate), temporal pole (mild) and middle temporal gyrus (mild) - moderate atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (severe) and posterior insula (mild) - mild atrophy of the parietal lobe - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - severe bilateral atrophy of the caudate, more pronounced on the left - severe bilateral atrophy of the accumbens, more pronounced on the left - moderate atrophy of the hippocampus, more pronounced on the left - no evidence of atrophy in the basal forebrain - mild atrophy of the putamen, more pronounced on the left - mild atrophy of the pallidum, more pronounced on the left - moderate left atrophy of the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle, more pronounced on the left - mild left enlargement of the lateral ventricle - severe enlargement of the external csf - moderate enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0050_MR_T1_MPRAGE_long_S2_DIS3D__br_raw_20110718081422479_31_S115040_I245234

On a T1-weighted brain MRI of a 75-year-old female subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the insular cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: anterior insula (severe), central operculum (mild) and posterior insula (mild) - moderate bilateral atrophy of the frontal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: precentral gyrus (severe), supplementary motor cortex (moderate), precentral gyrus medial segment (mild), middle frontal gyrus (mild) and sup. frontal gyrus (mild) - mild bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: parahippocampal gyrus (mild), middle cingulate gyrus (mild) and anterior cingulate gyrus (mild) - atrophies of temporal lobe on fusiform gyrus (moderate) and temporal pole (mild) - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the putamen, more pronounced on the right - severe bilateral atrophy of the amygdala, more pronounced on the right - moderate bilateral atrophy of the caudate, more pronounced on the right - moderate atrophy of the pallidum, more pronounced on the right - mild bilateral atrophy of the ventral dc, more pronounced on the right - mild bilateral atrophy of the accumbens - no evidence of atrophy in the hippocampus - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - severe enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0051_MR_t1_mprage_S3_DIS3D_br_raw_20110718094134503_20_S115066_I245269

On a T1-weighted brain MRI of a 68-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: temporal pole (severe), middle temporal gyrus (severe), planum polare (moderate), inf. temporal gyrus (moderate), sup. temporal gyrus (mild) and fusiform gyrus (mild) - mild atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: posterior insula (moderate) and anterior insula (mild) - mild focal atrophy of parietal lobe on sup. parietal lobule - atrophies of limbic cortex on entorhinal area (moderate) and parahippocampal gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - moderate bilateral atrophy of the putamen, more pronounced on the left - moderate bilateral atrophy of the hippocampus - moderate bilateral atrophy of the thalamus, more pronounced on the left - moderate bilateral atrophy of the accumbens - mild atrophy of the caudate, more pronounced on the left - mild atrophy of the pallidum, more pronounced on the left - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - mild enlargement of the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0100_MR_T1_mprage_S3_DIS3D_br_raw_20120830090711252_25_S164010_I327985

On a T1-weighted brain MRI of a 73-year-old female subject, we observed the following: For the cerebral cortex: - severe atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: temporal pole (severe), fusiform gyrus (moderate), inf. temporal gyrus (mild) and planum polare (mild) - mild focal atrophy of frontal lobe on gyrus rectus - mild focal atrophy of limbic cortex on entorhinal area - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - moderate atrophy of the hippocampus, more pronounced on the left - mild atrophy of the accumbens, more pronounced on the left - mild atrophy of the putamen, more pronounced on the left - mild left atrophy of the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the caudate - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the ventral dc For the ventricles: - severe enlargement of the inf. lateral ventricle, more pronounced on the left - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0123_MR_T1_mprage_S3_DIS3D_br_raw_20170817143341516_132_S598459_I892127

On a T1-weighted brain MRI of a 62-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: middle frontal gyrus (severe), precentral gyrus (mild), orbital inf. frontal gyrus (mild), triangular inf. frontal gyrus (mild), posterior orbital gyrus (mild) and supplementary motor cortex (mild) - moderate atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (moderate), central operculum (mild) and frontal operculum (mild) - mild atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (moderate) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the caudate, more pronounced on the left - severe bilateral atrophy of the putamen, more pronounced on the left - mild bilateral atrophy of the amygdala - mild atrophy of the accumbens, more pronounced on the left - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the hippocampus For the ventricles: - severe bilateral enlargement of the lateral ventricle - moderate enlargement of the inf. lateral ventricle, more pronounced on the left - mild enlargement of the 3rd ventricle - mild enlargement of the external csf - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0194_MR_T1_mprage_S3_DIS3D_br_raw_20140831195557073_107_S229201_I441537

On a T1-weighted brain MRI of a 77-year-old female subject, we observed the following: For the cerebral cortex: - moderate atrophy of the insular cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: posterior insula (moderate), parietal operculum (moderate), anterior insula (mild) and central operculum (mild) - moderate atrophy of the parietal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: angular gyrus (mild) - mild atrophy of the temporal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: transverse temporal gyrus (mild), planum temporale (moderate) and inf. temporal gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - mild bilateral atrophy of the putamen, more pronounced on the right - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the pallidum - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0356_MR_t1_mprage__br_raw_20170628174605905_151_S577026_I866521

On a T1-weighted brain MRI of a 61-year-old female subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: medial frontal cortex (severe), gyrus rectus (severe), middle frontal gyrus (severe), sup. frontal gyrus (severe), lateral orbital gyrus (moderate), sup. frontal gyrus medial segment (moderate), opercular inf. frontal gyrus (mild), medial orbital gyrus (mild), posterior orbital gyrus (mild), orbital inf. frontal gyrus (mild), triangular inf. frontal gyrus (mild) and anterior orbital gyrus (mild) - moderate bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (severe) - moderate bilateral atrophy of the insular cortex, with focal volume reduction observed in the following subregions: anterior insula (severe) and frontal operculum (moderate) - mild atrophy of the temporal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: temporal pole (moderate), fusiform gyrus (mild) and sup. temporal gyrus (mild) - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the accumbens, more pronounced on the right - severe bilateral atrophy of the amygdala, more pronounced on the right - mild right atrophy of the caudate - mild right atrophy of the putamen - mild right atrophy of the hippocampus - no evidence of atrophy in the ventral dc - no evidence of atrophy in the pallidum - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the thalamus For the ventricles: - mild right enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - severe enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD