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ADNI_036_S_4389_MR_MPRAGE_br_raw_20111208111740515_160_S132147_I270466

On a T1-weighted brain MRI of a 82-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on precentral gyrus (mild), sup. frontal gyrus medial segment (mild) and supplementary motor cortex (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

CN

ADNI_041_S_4014_MR_MPRAGE_br_raw_20110419162428038_47_S104714_I228302

On a T1-weighted brain MRI of a 81-year-old male subject, we observed the following: For the cerebral cortex: - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

ADNI_016_S_4963_MR_Accelerated_SAG_IR-SPGR__br_raw_20121011113527783_63_S170458_I339508

On a T1-weighted brain MRI of a 72-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on gyrus rectus - mild focal atrophy of limbic cortex on posterior cingulate gyrus - atrophies of insular cortex on posterior insula (mild) and frontal operculum (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - mild bilateral atrophy of the caudate - mild bilateral atrophy of the hippocampus - mild atrophy of the amygdala - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

ADNI_070_S_4692_MR_MPRAGE_br_raw_20120508114822245_48_S149506_I302279

On a T1-weighted brain MRI of a 84-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on inf. temporal gyrus - mild focal atrophy of parietal lobe on supramarginal gyrus - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - mild atrophy of the hippocampus, more pronounced on the left - mild atrophy of the accumbens, more pronounced on the right - mild atrophy of the putamen, more pronounced on the left - mild atrophy of the pallidum - mild left atrophy of the caudate - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

AD

NIFD_1_S_0098_MR_T1_mprage_S3_DIS3D_br_raw_20120819190827129_131_S161539_I324802

On a T1-weighted brain MRI of a 65-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: precentral gyrus (severe), middle frontal gyrus (moderate), triangular inf. frontal gyrus (mild), gyrus rectus (mild) and medial frontal cortex (mild) - mild atrophy of the occipital lobe, with focal volume reduction observed in the following subregions: inf. occipital gyrus (moderate), calcarine cortex (mild) and cuneus (mild) - moderate focal atrophy of limbic cortex on anterior cingulate gyrus - atrophies of insular cortex on central operculum (mild) and frontal operculum (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe For the subcortical structures: - no evidence of atrophy in the hippocampus - mild bilateral atrophy of the putamen - no evidence of atrophy in the basal forebrain - mild right atrophy of the accumbens - mild right atrophy of the pallidum - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild enlargement of the lateral ventricle - mild enlargement of the inf. lateral ventricle - moderate enlargement of the external csf - mild enlargement of the 3rd ventricle - mild enlargement of the 4th ventricle

FTD

NIFD_1_S_0342_MR_T1_mprage_S3_DIS3D_br_raw_20170629015155735_37_S578007_I867814

On a T1-weighted brain MRI of a 56-year-old male subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (moderate) and frontal operculum (mild) - severe atrophy of the frontal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: middle frontal gyrus (moderate), sup. frontal gyrus medial segment (mild), opercular inf. frontal gyrus (moderate), medial orbital gyrus (moderate), triangular inf. frontal gyrus (mild), posterior orbital gyrus (mild), gyrus rectus (mild), lateral orbital gyrus (mild), sup. frontal gyrus (mild) and orbital inf. frontal gyrus (mild) - mild focal atrophy of temporal lobe on temporal pole - mild focal atrophy of parietal lobe on postcentral gyrus medial segment - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the accumbens, more pronounced on the left - severe atrophy of the putamen, more pronounced on the left - moderate atrophy of the caudate, more pronounced on the left - mild atrophy of the thalamus, more pronounced on the left - mild atrophy of the hippocampus, more pronounced on the left - no evidence of atrophy in the basal forebrain - mild left atrophy of the amygdala - mild left atrophy of the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - moderate enlargement of the lateral ventricle, more pronounced on the left - severe left enlargement of the inf. lateral ventricle - severe enlargement of the external csf - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0129_MR_T1_mprage_S3_DIS3D_br_raw_20130719145834882_139_S195789_I381649

On a T1-weighted brain MRI of a 66-year-old female subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: opercular inf. frontal gyrus (severe), medial orbital gyrus (severe), medial frontal cortex (severe), middle frontal gyrus (severe), posterior orbital gyrus (moderate), lateral orbital gyrus (mild), gyrus rectus (mild), sup. frontal gyrus (mild) and sup. frontal gyrus medial segment (mild) - severe bilateral atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (severe), frontal operculum (moderate) and posterior insula (mild) - severe bilateral atrophy of the limbic cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior cingulate gyrus (severe) - atrophies of temporal lobe on middle temporal gyrus (mild) and temporal pole (mild) - mild focal atrophy of parietal lobe on supramarginal gyrus - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the accumbens, more pronounced on the left - severe bilateral atrophy of the amygdala, more pronounced on the left - moderate bilateral atrophy of the caudate, more pronounced on the left - mild atrophy of the hippocampus, more pronounced on the left - no evidence of atrophy in the basal forebrain - moderate left atrophy of the putamen - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild enlargement of the inf. lateral ventricle, more pronounced on the left - mild enlargement of the lateral ventricle - severe enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0110_MR_T1_mprage_S3_DIS3D_br_raw_20121010112828959_149_S170350_I339348

On a T1-weighted brain MRI of a 63-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: posterior orbital gyrus (severe), opercular inf. frontal gyrus (moderate), gyrus rectus (mild), triangular inf. frontal gyrus (mild), middle frontal gyrus (mild) and orbital inf. frontal gyrus (mild) - mild focal atrophy of parietal lobe on postcentral gyrus - moderate focal atrophy of limbic cortex on anterior cingulate gyrus - mild focal atrophy of insular cortex on anterior insula - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - no evidence of atrophy in the basal forebrain - mild bilateral atrophy of the accumbens - mild atrophy of the caudate - mild atrophy of the putamen - no evidence of atrophy in the amygdala - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - moderate enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0073_MR_t1_mprage_S3_DIS3D_br_raw_20120122183647618_26_S138127_I280044

On a T1-weighted brain MRI of a 75-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on precentral gyrus - atrophies of temporal lobe on sup. temporal gyrus (moderate) and middle temporal gyrus (mild) - mild focal atrophy of parietal lobe on postcentral gyrus medial segment - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the putamen, more pronounced on the left - mild atrophy of the ventral dc - mild left atrophy of the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - mild left enlargement of the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0345_MR_T1_mprage_S3_DIS3D_br_raw_20170629030000937_120_S578196_I868070

On a T1-weighted brain MRI of a 57-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on precentral gyrus - mild focal atrophy of insular cortex on parietal operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild left enlargement of the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0257_MR_t1_mprage__br_raw_20170628125014072_7_S576243_I865552

On a T1-weighted brain MRI of a 65-year-old female subject, we observed the following: For the cerebral cortex: - mild bilateral atrophy of the insular cortex, with focal volume reduction observed in the following subregions: parietal operculum (mild) - mild atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: postcentral gyrus (mild) - atrophies of frontal lobe on anterior orbital gyrus (mild) and sup. frontal gyrus (mild) - mild focal atrophy of temporal lobe on temporal pole - mild focal atrophy of occipital lobe on inf. occipital gyrus - no evidence of atrophy in the limbic cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0302_MR_t1_mprage__br_raw_20170628142407176_107_S576591_I865977

On a T1-weighted brain MRI of a 66-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on orbital inf. frontal gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the ventral dc - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0301_MR_t1_mprage__br_raw_20160903223821943_13_S496932_I773276

On a T1-weighted brain MRI of a 61-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on triangular inf. frontal gyrus (mild), medial orbital gyrus (mild) and posterior orbital gyrus (mild) - severe focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - moderate bilateral atrophy of the accumbens, more pronounced on the right - mild bilateral atrophy of the putamen - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0242_MR_t1_mprage__br_raw_20170628115739412_104_S576177_I865466

On a T1-weighted brain MRI of a 63-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on anterior orbital gyrus (mild) and sup. frontal gyrus medial segment (mild) - atrophies of temporal lobe on temporal pole (mild), planum polare (mild) and middle temporal gyrus (mild) - moderate focal atrophy of parietal lobe on postcentral gyrus medial segment - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the amygdala - mild bilateral atrophy of the caudate - mild bilateral atrophy of the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

CN

NIFD_1_S_0165_MR_T1_mprage_S3_DIS3D_br_raw_20150522122207303_150_S261053_I494288

On a T1-weighted brain MRI of a 68-year-old female subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on medial frontal cortex (moderate) and posterior orbital gyrus (mild) - mild focal atrophy of parietal lobe on angular gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild bilateral enlargement of the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0031_MR_t1_mprage_S3_DIS3D_br_raw_20110430185206528_111_S106603_I231172

On a T1-weighted brain MRI of a 69-year-old female subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: entorhinal area (severe) and parahippocampal gyrus (moderate) - mild atrophy of the temporal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: temporal pole (severe), fusiform gyrus (mild) and planum polare (mild) - mild atrophy of the insular cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: anterior insula (moderate) and posterior insula (mild) - atrophies of frontal lobe on gyrus rectus (mild) and subcallosal area (mild) - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the accumbens, more pronounced on the right - severe bilateral atrophy of the hippocampus, more pronounced on the left - severe bilateral atrophy of the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0036_MR_T1_MPRAGE_long_S4_DIS3D__br_raw_20110517214854226_17_S109250_I235487

On a T1-weighted brain MRI of a 59-year-old male subject, we observed the following: For the cerebral cortex: - severe atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: temporal pole (severe), fusiform gyrus (moderate), inf. temporal gyrus (mild), middle temporal gyrus (mild) and sup. temporal gyrus (mild) - moderate bilateral atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: entorhinal area (moderate), anterior cingulate gyrus (moderate) and parahippocampal gyrus (mild) - mild atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (moderate) and posterior insula (mild) - mild focal atrophy of frontal lobe on gyrus rectus - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - moderate bilateral atrophy of the accumbens, more pronounced on the left - moderate atrophy of the hippocampus, more pronounced on the left - mild atrophy of the putamen, more pronounced on the left - mild atrophy of the caudate, more pronounced on the left - mild atrophy of the pallidum, more pronounced on the left - no evidence of atrophy in the basal forebrain - mild left atrophy of the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe enlargement of the inf. lateral ventricle, more pronounced on the left - mild left enlargement of the lateral ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0069_MR_t1_mprage_S3_DIS3D_br_raw_20111209134632915_64_S132448_I270916

On a T1-weighted brain MRI of a 50-year-old male subject, we observed the following: For the cerebral cortex: - moderate atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: temporal pole (severe), fusiform gyrus (mild) and middle temporal gyrus (mild) - atrophies of frontal lobe on medial frontal cortex (mild), gyrus rectus (mild), lateral orbital gyrus (mild) and medial orbital gyrus (mild) - mild focal atrophy of limbic cortex on entorhinal area - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - severe atrophy of the amygdala, more pronounced on the left - mild left atrophy of the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the caudate - no evidence of atrophy in the pallidum - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe enlargement of the inf. lateral ventricle, more pronounced on the left - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0092_MR_T1_mprage_S3_DIS3D_br_raw_20120819145642992_94_S161426_I324669

On a T1-weighted brain MRI of a 65-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: middle frontal gyrus (moderate), posterior orbital gyrus (moderate), gyrus rectus (moderate), frontal pole (mild), anterior orbital gyrus (mild), sup. frontal gyrus medial segment (mild) and orbital inf. frontal gyrus (mild) - moderate bilateral atrophy of the insular cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: anterior insula (moderate) and parietal operculum (mild) - moderate bilateral atrophy of the parietal lobe, with focal volume reduction observed in the following subregions: supramarginal gyrus (mild) and precuneus (mild) - atrophies of temporal lobe on temporal pole (mild) and fusiform gyrus (mild) - moderate focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the occipital lobe For the subcortical structures: - moderate bilateral atrophy of the caudate, more pronounced on the right - moderate bilateral atrophy of the accumbens - no evidence of atrophy in the basal forebrain - mild bilateral atrophy of the putamen - mild atrophy of the amygdala - mild left atrophy of the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0125_MR_T1_mprage_S3_DIS3D_br_raw_20130719153222260_3_S195826_I381695

On a T1-weighted brain MRI of a 66-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of occipital lobe on lingual gyrus - mild focal atrophy of limbic cortex on entorhinal area - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - mild atrophy of the thalamus - mild right atrophy of the pallidum - no evidence of atrophy in the hippocampus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0144_MR_T1_mprage_S3_DIS3D_br_raw_20170815133418972_106_S595419_I888037

On a T1-weighted brain MRI of a 47-year-old male subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the frontal lobe, more pronounced on the right, with focal volume reduction observed in the following subregions: opercular inf. frontal gyrus (moderate), sup. frontal gyrus medial segment (mild), frontal pole (mild) and sup. frontal gyrus (mild) - moderate atrophy of the insular cortex, more pronounced on the right, with focal volume reduction observed in the following subregions: anterior insula (mild), parietal operculum (mild) and frontal operculum (mild) - mild focal atrophy of limbic cortex on middle cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - mild atrophy of the putamen, more pronounced on the right - mild atrophy of the caudate, more pronounced on the right - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the thalamus - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - moderate bilateral enlargement of the inf. lateral ventricle - moderate bilateral enlargement of the lateral ventricle - mild enlargement of the 3rd ventricle - mild enlargement of the external csf - no evidence of enlargements in the 4th ventricle

FTD

NIFD_1_S_0166_MR_T1_mprage_S3_DIS3D_br_raw_20140901080234423_109_S229320_I441668

On a T1-weighted brain MRI of a 61-year-old male subject, we observed the following: For the cerebral cortex: - moderate bilateral atrophy of the frontal lobe, with focal volume reduction observed in the following subregions: middle frontal gyrus (mild) - mild atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: anterior insula (mild) and frontal operculum (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex For the subcortical structures: - mild bilateral atrophy of the hippocampus - mild left atrophy of the thalamus - mild left atrophy of the accumbens - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the pallidum - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle - moderate bilateral enlargement of the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0195_MR_T1_mprage_S3_DIS3D_br_raw_20140901084455878_123_S229378_I441735

On a T1-weighted brain MRI of a 56-year-old male subject, we observed the following: For the cerebral cortex: - severe bilateral atrophy of the temporal lobe, more pronounced on the left, with focal volume reduction observed in the following subregions: temporal pole (severe), inf. temporal gyrus (severe), middle temporal gyrus (moderate), fusiform gyrus (mild) and sup. temporal gyrus (mild) - moderate atrophy of the limbic cortex, with focal volume reduction observed in the following subregions: entorhinal area (moderate), parahippocampal gyrus (moderate) and anterior cingulate gyrus (mild) - mild atrophy of the insular cortex, more pronounced on the left, with focal volume reduction observed in the following subregions: posterior insula (severe) and anterior insula (mild) - mild focal atrophy of frontal lobe on medial frontal cortex - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - severe bilateral atrophy of the amygdala, more pronounced on the left - moderate atrophy of the hippocampus, more pronounced on the left - mild atrophy of the accumbens, more pronounced on the left - moderate left atrophy of the putamen - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the caudate - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the inf. lateral ventricle, more pronounced on the left - no evidence of enlargements in the lateral ventricle - mild enlargement of the external csf - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle

FTD

NIFD_3_S_0003_MR_t1_mprage_S3_DIS3D_br_raw_20160518175540145_38_S442730_I709721

On a T1-weighted brain MRI of a 62-year-old male subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on middle frontal gyrus (mild) and orbital inf. frontal gyrus (mild) - mild focal atrophy of temporal lobe on sup. temporal gyrus - moderate focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - mild left atrophy of the thalamus - no evidence of atrophy in the caudate - no evidence of atrophy in the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

FTD

NIFD_1_S_0210_MR_T1_mprage_S3_DIS3D_br_raw_20170816162543426_142_S596683_I889731

On a T1-weighted brain MRI of a 64-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on sup. frontal gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0218_MR_T1_mprage_S3_DIS3D_br_raw_20140908131021468_157_S230417_I443026

On a T1-weighted brain MRI of a 53-year-old male subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on fusiform gyrus - mild focal atrophy of parietal lobe on angular gyrus - mild focal atrophy of limbic cortex on anterior cingulate gyrus - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - mild enlargement of the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - mild enlargement of the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0224_MR_T1_mprage_S3_DIS3D_br_raw_20170817110538505_10_S597571_I890963

On a T1-weighted brain MRI of a 55-year-old female subject, we observed the following: For the cerebral cortex: - atrophies of frontal lobe on triangular inf. frontal gyrus (moderate) and sup. frontal gyrus medial segment (mild) - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild bilateral atrophy of the pallidum - mild atrophy of the thalamus - mild left atrophy of the accumbens - no evidence of atrophy in the caudate - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the putamen - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0231_MR_t1_mprage__br_raw_20160902114602280_102_S495583_I771719

On a T1-weighted brain MRI of a 70-year-old male subject, we observed the following: For the cerebral cortex: - mild atrophy of the limbic cortex - mild focal atrophy of frontal lobe on subcallosal area - mild focal atrophy of insular cortex on central operculum - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe For the subcortical structures: - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0278_MR_t1_mprage__br_raw_20160903203205103_30_S496697_I773003

On a T1-weighted brain MRI of a 68-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of temporal lobe on sup. temporal gyrus - atrophies of occipital lobe on calcarine cortex (mild) and lingual gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0281_MR_T1_mprage_S3_DIS3D_br_raw_20170817102624125_146_S597364_I890694

On a T1-weighted brain MRI of a 73-year-old female subject, we observed the following: For the cerebral cortex: - atrophies of temporal lobe on temporal pole (mild) and fusiform gyrus (mild) - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the caudate - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_1_S_0291_MR_t1_mprage__br_raw_20160903213644757_38_S496820_I773145

On a T1-weighted brain MRI of a 54-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of frontal lobe on precentral gyrus - mild focal atrophy of occipital lobe on calcarine cortex - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the parietal lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - mild left atrophy of the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the putamen - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN

NIFD_2_S_0023_MR_MT1__GradWarp__N3m_Br_20120907160512868_S164342_I332341

On a T1-weighted brain MRI of a 46-year-old female subject, we observed the following: For the cerebral cortex: - mild focal atrophy of parietal lobe on postcentral gyrus medial segment - no evidence of atrophy in the frontal lobe - no evidence of atrophy in the temporal lobe - no evidence of atrophy in the occipital lobe - no evidence of atrophy in the limbic cortex - no evidence of atrophy in the insular cortex For the subcortical structures: - no evidence of atrophy in the putamen - no evidence of atrophy in the accumbens - no evidence of atrophy in the amygdala - no evidence of atrophy in the basal forebrain - no evidence of atrophy in the caudate - no evidence of atrophy in the hippocampus - no evidence of atrophy in the pallidum - no evidence of atrophy in the thalamus - no evidence of atrophy in the ventral dc For the ventricles: - severe bilateral enlargement of the lateral ventricle - no evidence of enlargements in the inf. lateral ventricle - no evidence of enlargements in the 3rd ventricle - no evidence of enlargements in the 4th ventricle - no evidence of enlargements in the external csf

CN